No, it's not an echo question.
http://dictionary.reference.com/browse/echo%20question
"You know what?" is usually the introduction to some surprising news.
Ex:
1st person: You know what?
2nd person: No, what?
1st person: My boyfriend gave me a dozen red roses!
"What do you know?" is different. It can be said sarcastically as if in doubt about what the other person just said. It can also be a straight question -- usually followed by something specific -- like -- "What do you know about astronomy?"
e.g. You know what?
(I think this expression is frequently used. What is the meaning of this one? Is it called an echo question? What is the difference between 'You know what?' and 'What do you know?')
2 answers
" What do you know!" can also be used as an expression of surprise.
As, The soccer team won the state championship. Well, what do you know!
As, The soccer team won the state championship. Well, what do you know!