2) Compound called Moniliformin has been shown to affect pyruvate dehydrogenase complex activity and inhibit the conversion of pyruvate to acetyl coA. Without knowing specific details on how this drug exert its inhibitory effect, could you outline potential mechanisms through which monlilformin can inhibit pyruvate dehydrogenase complex.
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does this give you a clue? https://www.ncbi.nlm.nih.gov/pubmed/23471124
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