Where is the pyruvate dehydrogenase and alpha ketone dehydrogenase located

Answer 1

Pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (AKGDH) are both important enzyme complexes involved in cellular metabolism.

1. Pyruvate Dehydrogenase (PDH):

   • Location: PDH is located in the mitochondrial matrix of eukaryotic cells. It plays a crucial role in converting pyruvate (derived from glycolysis) into acetyl-CoA, which then enters the citric acid cycle (Krebs cycle) for further energy production.

2. Alpha-Ketoglutarate Dehydrogenase (AKGDH):

   • Location: Like PDH, alpha-ketoglutarate dehydrogenase is also located in the mitochondrial matrix. This enzyme complex catalyzes the conversion of alpha-ketoglutarate to succinyl-CoA in the citric acid cycle, an important step in energy metabolism.

Both enzymes are integral to the metabolic pathways that generate ATP and are found in the mitochondria due to their roles in aerobic respiration.