Question

What happens if there is a mutation in the DNA binding domain, a mutation that inhibits the binding of a hormone, and a mutation where there is no effect of hormone binding but blocks the ability of hormone to interact with coactivator proteins? These are all three different cases. Thanks

Answer 1

if there is a mutation in the DNA binding domain: Whatever the end function is supposed to be, it is likely to have a transcription error.
a mutation that inhibits the binding of a hormone: The hormone will be ineffective, as my body does not react to thyroid hormone.
a mutation where there is no effect of hormone binding but blocks the ability of hormone to interact with coactivator proteins: Again, no normal response to the hormone.