How did systems of Spanish landholding and mining affect native peoples?

The Spanish had and affected the way the natives lives and work. They was tortured them till they did what the Spaniards wanted history and enchain them. Native peoples later reinterpreted their histories to accept their conditions, for the Christianity to elucidate actions.
These and the original Americans were often forced to pay taxes to the Spanish government and were punished for disobeying their laws. In previous regions, the Natives remained ethnically distinct, and to resist for more than two centuries.

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I assume this is your answer? You're correct, but not clearly stated, in that Native Americans were enslaved. I'm not sure about taxation. Make sure your source for that information is solid.

I'm also no sure that Native Americans revised their own history to accommodate being enslaved. Maybe some did, under influence from Missionaries, but I doubt it "stuck."