1. What's the matter with you?

2. What's up with you?
3. What happened to you?
4. What's happening to you?
5. What's going on with you?
6. What happened to you?
7. What's happening to you?
8. What's wrong with you?

(Did I use correct prepositions? Do I have to use 'with' or 'to'?)

2 answers

Just as you have them!

Sra
just as they are all right