Before the American Revolution, the four primary indigenous nations that formed in what is now South Carolina were:
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Catawba: The Catawba people were located along the Catawba River and were known for their agricultural practices and pottery.
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Cherokee: The Cherokee Nation had a significant presence in the western part of South Carolina and surrounding areas, known for their complex social structures and political organization.
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Creek (Muscogee): Although primarily located in what is now Georgia and Alabama, the Creek people had interactions and established trade with communities in South Carolina.
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Yamasee: The Yamasee lived in the coastal regions and were involved in trade with European settlers. They played a significant role in the early colonial history of South Carolina.
These nations had rich cultures and played important roles in the region's history prior to and during the early phases of European colonization and the American Revolutionary period.