Write a comprehensive laboratory report on synthesis of aspirin including the Lab title, objective, apparatus chemicals, procedure, observation, results and conclusion

Answer 1

Title: Synthesis of Aspirin

Objective:
The objective of this experiment is to synthesize aspirin from salicylic acid and acetic anhydride, and to purify the product through recrystallization. The purity of the synthesized aspirin will be determined by melting point analysis and compared with the literature value.

Apparatus and Chemicals:
- Salicylic acid
- Acetic anhydride
- Sulfuric acid
- Distilled water
- Ice bath
- Buchner funnel
- Filter paper
- Melting point apparatus

Procedure:
1. In a 50 mL Erlenmeyer flask, mix 2.0 g of salicylic acid with 5.0 mL of acetic anhydride and 5 drops of sulfuric acid.
2. Heat the mixture gently on a steam bath for 15 minutes.
3. Allow the mixture to cool to room temperature and then place it in an ice bath for 5 minutes.
4. Slowly add 50 mL of distilled water to the flask and stir the mixture.
5. Filter the precipitate using a Buchner funnel and wash with cold water.
6. Recrystallize the product by dissolving it in hot water and allowing it to cool slowly.
7. Collect the crystals by vacuum filtration and air dry them.
8. Determine the melting point of the aspirin crystals using a melting point apparatus.

Observations:
- Initially, the mixture turned a yellow color as the reaction proceeded.
- A white precipitate formed upon cooling the mixture in the ice bath.
- The final aspirin crystals were white and fluffy.

Results:
The melting point of the synthesized aspirin was determined to be 135°C, which is consistent with the literature value of 138-140°C for pure aspirin.

Conclusion:
In this experiment, aspirin was successfully synthesized from salicylic acid and acetic anhydride. The product was purified through recrystallization and its purity was confirmed by melting point analysis. The melting point of the synthesized aspirin was found to be in close agreement with the literature value, indicating a high level of purity. Overall, the synthesis of aspirin was successful and the purity of the product was confirmed through experimental analysis.