Alexander Hamilton's plans to tax the American people were opposed by many southerners primarily because they did not want to bail the northerners out.
Hamilton's financial plans included assuming state debts and creating a national bank, which many southern states viewed as disproportionately benefiting the northern economies that had accrued more debt during the Revolutionary War. Southerners felt that they were being asked to support economic policies that primarily favored the northern states and their interests, which fueled their opposition to Hamilton's tax measures.
While concerns about federal authority and the right to tax were also present, the specific resentment towards the redistribution of financial responsibility was a significant factor in the southern opposition to Hamilton's financial plans.