The key individuals involved in the conflict surrounding William McIntosh and the Treaties of Indian Springs included:
- William McIntosh - A Creek chief who signed the treaties.
- John Forrest - A U.S. Indian agent involved in treaty negotiations.
- Andrew Jackson - President of the United States at the time, supportive of the treaties.
- Members of the Creek Nation - Other leaders and tribesmen, both supporters and opponents of McIntosh.
- George Troupe - A Georgia politician who played a role in the treaty process.
The treaties themselves were a significant point of conflict within the Creek Nation, leading to divisions among the tribes.