The two statements that best describe the similarities between the Middle Colonies and the New England Colonies are:
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Both had mostly good relationships with Native Americans, even though there were some conflicts.
Both regions experienced initial cooperation and trade with Native American tribes, although conflicts did arise over land and resources. -
Both had some groups that settled for religious reasons.
Both regions included settlers who were motivated by religious beliefs: the New England Colonies were primarily settled by Puritans and Pilgrims, while the Middle Colonies had a more diverse population that included Quakers, Catholics, and other religious groups.
The other statements do not accurately reflect the historical contexts of the two regions.