The following statements accurately describe the social structure of the Spanish colonies:
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Those who came from Spain, peninsulares, held all the power and wealth and the best positions in the colonies.
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Mixed race people called Mestizo were free but usually poor.
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People of Spanish descent born in America were called Creoles and rarely obtained jobs with the government.
The statement about Native peoples suffering from prejudice due to supposed laziness is a mischaracterization and reflects a biased viewpoint rather than an accurate description of their social standing. Additionally, while there may have been some degree of social mobility, the social structure in Spanish colonies was generally rigid, so the last statement about the social structure becoming more flexible is not entirely correct.
Thus, the first three responses are correct.