The correct statement that explains how genetic information is organized from smallest to largest in the eukaryotic cell nucleus is:
DNA makes up chromosomes, which make up genes.
However, it's worth noting that a more accurate description is that genes are segments of DNA, and DNA is organized into chromosomes. So, while the phrasing "genes make up DNA" is incorrect, the general understanding is that DNA contains genes, and it is organized into structures called chromosomes.