The most accurate statement that summarizes how the differences in military technology between the Spaniards and the Aztec and Inca affected their battles is:
While the Indigenous forces would number in the thousands at times when battling the Europeans, they were still no match for the military prowess of the Spaniards.
This reflects the impact of European military technology, such as guns and cavalry, which, combined with tactics and strategy, gave the Spaniards a significant advantage despite often being outnumbered.