The statement that accurately describes the role of key individuals in the rise and spread of Islam is:
Muhammad was the leader and founder of Islam in its origin, the companions spread the religion, and the first four caliphs expanded the Islamic Empire after Muhammad’s death.
This statement outlines the foundational role of Muhammad, acknowledges the contributions of his companions in spreading the religion, and highlights the significant role played by the first four caliphs in the expansion of the Islamic Empire after Muhammad's death.