To accurately answer your question, it would be helpful to know what "Region 1," "Region 2," "Region 3," and "Region 4" refer to, as regions can vary based on the context (e.g., geographic, demographic, or economic).
However, during the period of industrialization in the United States (roughly late 19th century to early 20th century), the Northeast region, particularly areas like New York City, received a large influx of immigrants due to job opportunities in factories and industries. Cities such as Chicago and later Los Angeles also received significant numbers of immigrants.
If you provide specific information about what regions you are referring to, I can offer a more precise answer.