An integral membrane protein is best described by the option: "a protein with one end in the cytoplasm and the other end in the extracellular space."
Integral membrane proteins span the lipid bilayer of the membrane, meaning they have regions that are embedded within the hydrophobic core of the membrane, with parts exposed to both the cytoplasm and the extracellular environment. This distinguishes them from peripheral proteins, which are typically found on the surface of the membrane or are loosely attached.