D. Comanche
The Comanche were not one of the "Five Nations" most affected by the Indian Removal Act, which primarily impacted the Cherokee, Creek, Chickasaw, Choctaw, and Seminole nations.
Responses


A CreekCreek


B CherokeeCherokee


C ChickasawChickasaw


D Comanche
1 answer
D. Comanche
The Comanche were not one of the "Five Nations" most affected by the Indian Removal Act, which primarily impacted the Cherokee, Creek, Chickasaw, Choctaw, and Seminole nations.