The statement that best describes the political and religious situation in Europe at the end of the sixteenth century is:
A. Europe remained divided over political and religious issues.
By the end of the sixteenth century, Europe was characterized by significant religious divisions, primarily between Catholic and Protestant states, influenced by the Reformation and its aftermath. The situation was quite complex, with various regions and nations having different religious affiliations and political tensions arising from these divisions. The other options do not accurately reflect the broader situation across Europe at that time.