The most likely option to construct an argument against U.S. annexation of the Philippines would be:
a Sixto López
Sixto López was a prominent Filipino nationalist and critic of U.S. imperialism, making him a strong candidate for opposing the annexation. The other options, including William McKinley (who was in favor of annexation), the National Association of Manufacturers (which generally supported expansion and economic opportunities), and an imperialist, would not be likely to argue against the annexation.
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