The option that would lead to increased genetic variation in offspring is:
a DNA replication error in a gamete of an individual during meiosis.
This is because such errors can introduce new mutations that contribute to genetic diversity. The other options mentioned do not produce genetic variation in the same way:
- Asexual reproduction typically produces genetically identical offspring, resulting in no variation.
- Independent assortment occurs during meiosis, not mitosis, and it applies to the formation of gametes, contributing to variation, but the option incorrectly states it occurs during mitosis.
- Crossing over occurs during meiosis, not mitosis, and it does increase genetic variation, but the option incorrectly states it takes place in somatic cells instead of in gametes.
Thus, the correct choice is the first option regarding a DNA replication error during meiosis.