Detergents will disrupt the hydrogen bonds and non-polar hydrophobic interactions of proteins and denature them.
Detergents are amphipathic molecules, meaning they have both hydrophobic (water-repelling) and hydrophilic (water-attracting) parts. When detergents interact with proteins, they primarily affect the non-polar hydrophobic interactions that stabilize the protein's tertiary and quaternary structures. By inserting themselves between the nonpolar amino acid residues, they disrupt the hydrophobic core of the protein, leading to denaturation. Additionally, detergents can disrupt hydrogen bonds within the protein's structure, further contributing to the loss of the protein's native conformation.
Which of the following would happen if proteins are left with detergents?
Detergents will break the protein structure by breaking the positive and negative interactions in the protein chains.
Detergents will denature the protein by interrupting the intracovalent interactions of proteins.
Detergents will disrupt the hydrogen bonds and non-polar hydrophobic interactions of proteins and denatures it.
Detergents will disrupt the salt bridges between the amino acids in the polypeptide chain, thus denaturing the protein.
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