The direct effects of Pizarro’s and Cortés’s defeat of Native Americans include:
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Settlement and colonization in the Southwest under Spanish rule - This was a direct consequence of the conquests, as Spain sought to expand its territories and consolidate power in the Americas.
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Inspiration for other Europeans to begin explorations and settlement - The success of Pizarro and Cortés served as a significant motivation for other European powers to explore and colonize the Americas, leading to further expeditions and settlements.
The other two options, "settlement and colonization of Florida under Spanish rule" and "fighting between the Spanish and the French," were not direct effects of Pizarro’s and Cortés’s actions specifically related to their conquests of the Aztec and Inca empires.