Which of the following statements is true about feedback inhibition?

Question

There are no intermediates involved.

The substrate of one reaction becomes the product of another reaction.

The higher the concentration of the final product, the less likely that product will bind to the allosteric site of the enzyme.

When the concentration of the end product decreases, it reverses the inhibition and the reaction can proceed.

Answer 1

The true statement about feedback inhibition is:

When the concentration of the end product decreases, it reverses the inhibition and the reaction can proceed.

In feedback inhibition, the end product of a metabolic pathway acts as an inhibitor of an enzyme that is earlier in the pathway. When the concentration of the end product is high, it binds to the allosteric site of the enzyme, inhibiting the pathway. However, when the concentration of the end product decreases, the inhibition is relieved, allowing the pathway to proceed again.