The statement that best describes the effect of Matthew Perry’s expedition on Japan is:
"Perry’s arrival in Japan exposed the weaknesses of the Tokugawa Shogunate against the threat of a modernizing world."
Perry's expedition in 1853 and the subsequent Treaty of Kanagawa in 1854 forced Japan to open its ports to American trade, highlighting the shogunate's inability to resist Western pressures and signaling the beginning of the end for the Tokugawa regime. This moment marked a significant turning point in Japan's history, leading to modernization efforts and the eventual Meiji Restoration.