Which of the following statements accurately describes the function of a metabolic pathway involved in cellular respiration?

The function of the citric acid cycle is the transfer of electrons from pyruvate to NADH to O2.
The function of the bonding of acetic acid to the carrier molecule CoA to form acetyl CoA is the reduction of glucose to acetyl CoA.
The function of glycolysis is to begin catabolism by breaking glucose into two molecules of pyruvate, with a net yield of two ATP.

1 answer

Let's evaluate each statement regarding metabolic pathways involved in cellular respiration:

  1. The function of the citric acid cycle is the transfer of electrons from pyruvate to NADH to O2.

    • This statement is not accurate. The citric acid cycle (also known as the Krebs cycle) primarily involves the oxidation of acetyl-CoA to produce NADH and FADH2, but it does not directly transfer electrons from pyruvate to NADH to O2. Instead, it takes place after pyruvate has been converted to acetyl-CoA, and oxygen is utilized in the electron transport chain, not directly in the citric acid cycle.
  2. The function of the bonding of acetic acid to the carrier molecule CoA to form acetyl CoA is the reduction of glucose to acetyl CoA.

    • This statement is not accurate. The conversion of glucose to acetyl-CoA involves multiple steps, including glycolysis (which breaks down glucose into pyruvate) followed by the conversion of pyruvate to acetyl-CoA. The formation of acetyl-CoA from pyruvate does not involve the "reduction" of glucose; it is a decarboxylation process where CO2 is released, and NAD+ is reduced to NADH.
  3. The function of glycolysis is to begin catabolism by breaking glucose into two molecules of pyruvate, with a net yield of two ATP.

    • This statement is accurate. Glycolysis is the first step in cellular respiration and occurs in the cytoplasm, where one molecule of glucose (a six-carbon compound) is broken down into two molecules of pyruvate (a three-carbon compound). The process results in a net gain of two ATP molecules and two NADH molecules.

In conclusion, the only accurate statement is the third one: The function of glycolysis is to begin catabolism by breaking glucose into two molecules of pyruvate, with a net yield of two ATP.

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