The accurate statement that compares and contrasts eukaryotes and prokaryotes is:
Eukaryotes have a true nucleus and membrane-bound organelles, while prokaryotes lack a true nucleus and organelles.
This statement correctly highlights the key differences between the two types of cells. Eukaryotic cells possess a defined nucleus and various organelles that are enclosed by membranes, while prokaryotic cells do not have a true nucleus or membrane-bound organelles.