The Homestead Steel Strike was primarily led by issues related to labor conditions and management practices, particularly a significant wage cut and the desire of the Carnegie Steel Company to diminish union power. While workers being laid off due to lack of profitability could contribute to tensions, the strike itself was more directly a response to wage cuts and the aggressive stance of management against the union. Therefore, the most relevant factor would typically be the wage cuts and labor disputes rather than women’s wages specifically.
If you are trying to choose between the options provided, "Many workers were laid off due to failure of the factory to make a profit" would be the more appropriate answer related to the context of the Homestead Steel Strike.