It seems like there might be some information missing, such as the specific options corresponding to A, B, C, and D. However, I can provide information regarding how large or charged (polar) molecules typically cross the cell membrane.
Large or charged molecules usually pass through the cell membrane via:
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Transport Proteins: These include channel proteins, which provide pathways for specific molecules, and carrier proteins, which change shape to help transport molecules across the membrane.
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Endocytosis: For even larger molecules or particles, the cell can engulf them through a process called endocytosis.
If you provide the specific options corresponding to A, B, C, and D, I can help determine which one is the correct answer.