The following responses likely had the biggest negative impact on the Native Americans during the treaty-making process:
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Communication was difficult because of translation issues. - This would create misunderstandings and lead to misinterpretations of the terms being discussed, which could harm the interests of Native Americans.
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Native Americans did not trust Isaac Stevens' methods. - A lack of trust in the negotiator would make it difficult for Native Americans to engage in the process and feel confident that their interests were being represented.
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Stevens did not understand the role of tribal leaders. - Misunderstanding the leadership structure within Native American communities could lead to ineffective negotiations and exclusion of key voices in the process.
While the other options may have had some impact, the above three responses more significantly highlight fundamental issues in communication, trust, and understanding that directly affected Native Americans during the treaty-making process.