The impact of the creation of the smallpox vaccine on the Americas is best explained by the option:
It led to the complete eradication of the disease.
While the smallpox vaccine was instrumental in significantly reducing the incidence of smallpox, it is important to note that the complete eradication of smallpox occurred globally in 1980 as a result of widespread vaccination efforts, which included the Americas. The other options do not accurately reflect the primary impact of the smallpox vaccine.