Among the options provided, the statement that best explains the impact of the creation of the smallpox vaccine on the Americas is:
It led to the complete eradication of the disease.
While smallpox was not completely eradicated immediately after the introduction of the vaccine, the widespread use of vaccination eventually led to the global eradication of smallpox in 1980. The smallpox vaccine had a significant impact on public health, particularly in reducing mortality and preventing outbreaks in various populations, including Indigenous communities in the Americas.