The correct response is:
It led to the complete eradication of the disease.
The smallpox vaccine, developed by Edward Jenner in the late 18th century, ultimately contributed to the global eradication of smallpox in 1980, making it the first disease to be eradicated through vaccination. While the vaccine did not prevent the initial spread of the disease among Indigenous populations in the Americas (which was often exacerbated by contact with Europeans), its eventual success in eliminating smallpox is its most significant impact.