The correct choice that accurately compares prokaryotic and eukaryotic chromosomes is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
To clarify the other options:
- Prokaryotic chromosomes are typically circular, while eukaryotic chromosomes are linear.
- Prokaryotic chromosomes are not wrapped into nucleosomes; nucleosomes are a structure found in eukaryotic chromosomes.
- Prokaryotic chromosomes are generally smaller than eukaryotic chromosomes.
Therefore, the second option is the only one that correctly reflects the differences between prokaryotic and eukaryotic chromosomes.