The correct choice that compares prokaryotic and eukaryotic chromosomes is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
To clarify the other options:
- Prokaryotic chromosomes are typically circular, while eukaryotic chromosomes are linear.
- Prokaryotic chromosomes are generally smaller than eukaryotic chromosomes.
- Prokaryotic chromosomes are not wrapped into nucleosomes; nucleosomes are structures associated with eukaryotic DNA and are involved in its packaging.
So, the statement about the number of chromosomes is the correct comparison.