The correct choice that compares prokaryotic and eukaryotic chromosomes is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
To clarify the other options:
- Prokaryotic chromosomes are usually circular, while eukaryotic chromosomes are linear.
- Prokaryotic chromosomes are not wrapped into nucleosomes; that structure is associated with eukaryotic chromosomes.
- Prokaryotic chromosomes are typically much smaller than eukaryotic ones.