The best explanation of the effects of the First Cherokee War is:
The First Cherokee War ended in British victory and a new law that prohibited British-American colonists from settling farther into Indigenous territory.
The war, which took place from 1758 to 1761, was part of a broader conflict between European settlers and Indigenous nations, and it ultimately led to British military success. However, it did result in tighter regulations regarding settlement into Indigenous lands, although this would be difficult to enforce in the long run.