The response that best explains the causes of Pontiac’s Rebellion is:
Indigenous people fought the British to defend their territory and sovereignty.
Pontiac’s Rebellion (1763-1766) was primarily a conflict between various Native American tribes and the British colonial forces following the end of the French and Indian War. The indigenous groups were motivated by dissatisfaction with British policies and encroachments on their lands, leading to the desire to defend their territories and maintain their sovereignty.