The compounds C6H12O6 (glucose) and C3H6O (acetone) contain different types of atoms (carbon, hydrogen, and oxygen) and different numbers of each type.
C6H12O6 has 6 carbon atoms, 12 hydrogen atoms, and 6 oxygen atoms, while C3H6O has 3 carbon atoms, 6 hydrogen atoms, and 1 oxygen atom.
Therefore, the best description is: different types of atoms, different numbers of each type.