The most accurate claim regarding the molecules that cells need to release energy is:
Claim 5: Cells need glucose AND oxygen to release energy.
Cells primarily rely on glucose for energy through the process of cellular respiration, which occurs in the presence of oxygen (aerobic respiration). While amino acids can also be used for energy when glucose is not available, and oxygen is essential for more efficient energy production (specifically in aerobic organisms), glucose and oxygen together are critical for the most common and efficient energy production pathway in cells.
Other claims, like those focused solely on glucose or amino acids, do not provide a complete picture of how cells typically generate energy. Thus, Claim 5 is the most substantiated based on the primary energy-releasing mechanisms in cells.