The most likely way in which anti-poverty non-governmental organizations (NGOs) like Oxfam could help South America address political challenges is:
D) Ending poverty could reduce political instability and corruption.
By addressing poverty, NGOs can help create more stable and equitable societies, which can mitigate factors that contribute to political instability and corruption. Reducing poverty can empower individuals and communities, fostering a more engaged citizenry that is less susceptible to corrupt practices.