To simplify the expression \( 16 \frac{1}{4} \), we can first rewrite it as an improper fraction:
\[ 16 \frac{1}{4} = 16 + \frac{1}{4} = \frac{64}{4} + \frac{1}{4} = \frac{64 + 1}{4} = \frac{65}{4} \]
While this is a simplified improper fraction, if you meant how to simplify or interpret the number 16 as a base in a different context (e.g., numeral systems), it would depend on what you're asking about specifically.
If you're asking about factors of the base, 16 can be broken down into factors. The prime factorization of 16 is:
\[ 16 = 2^4 \]
Using this prime factorization can sometimes help in simplifying calculations involving powers or roots that include 16.
If you meant something else, please clarify so I can provide a more accurate answer!