To determine the expression that represents the calculation "multiply the difference of 381 and 22 by 16," we need to break it down:
- Find the difference of 381 and 22: This is calculated as \( 381 - 22 \).
- Multiply that difference by 16: This would be \( (381 - 22) \times 16 \).
Thus, the expression that represents the calculation is:
C) \( (381 - 22) \times 16 \)