To simplify the expression \( x^3(2 + y^5) \), we apply the distributive property:
\[ x^3(2 + y^5) = x^3 \cdot 2 + x^3 \cdot y^5 = 2x^3 + x^3y^5 \]
So, the expression \( x^3(2 + y^5) \) is equivalent to \( 2x^3 + x^3y^5 \).
Therefore, the correct response is:
2x³ + x³y⁵