To find the best estimate of the product of \( 281 \times 2.16 \), we can round the numbers to make the multiplication simpler.
- Round \( 281 \) to \( 300 \).
- Round \( 2.16 \) to \( 2 \).
Now, we multiply the rounded numbers:
\[ 300 \times 2 = 600 \]
Next, let's evaluate the other options to see how they compare as estimates:
- \( 200 \times 2 = 400 \)
- \( 300 \times 3 = 900 \)
- \( 250 \times 2 = 500 \)
Among the options:
- \( 300 \times 3 = 900 \)
- \( 200 \times 2 = 400 \)
- \( 300 \times 2 = 600 \)
- \( 250 \times 2 = 500 \)
The best estimate given the options for \( 281 \times 2.16 \) is:
\[ \boxed{300 \times 2} \]