The body cavity that affords the least protection to its internal structures is the ventral body cavity, particularly its subdivisions: the thoracic cavity and the abdominal cavity.
While the thoracic cavity is protected by the rib cage to some extent, the abdominal cavity, which houses vital organs such as the stomach, liver, intestines, and others, is less protected and is only covered by muscle and skin. This anatomical arrangement makes the abdominal cavity more susceptible to injury compared to other body cavities, like the cranial cavity (which is protected by the skull) and the spinal cavity (protected by the vertebral column).