Based on the information typically available regarding population declines in the context of historical events in Mexico, here's how you might answer the questions:
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Which area lost the most in percentage decline?
- Valley of Mexico (This area often experienced significant demographic changes, especially after the Spanish conquest.)
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How many years did it take for this decline in population?
- 5 (This is a common estimate for the period of significant population decline following European contact.)
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What could cause such a massive decline in population?
- Disease (Epidemics brought by Europeans, such as smallpox, devastatingly affected indigenous populations.)
Please verify these answers with specific study materials or data, as they reflect general historical knowledge.