The best answer to why Europeans brought widespread changes among American Indians is: A large movement of people always brings changes to communities.
This concept encapsulates the idea that when different groups come into contact—particularly in significant numbers—there is often an exchange of ideas, technologies, customs, and resources. The arrival of Europeans in North America led to profound changes in the social, economic, and political structures of Native American societies due to factors such as trade, colonization, conflict, and the introduction of new technologies and ideas.