If a cell lacked smooth endoplasmic reticulum (smooth ER), the most relevant consequence would be:
It would not be able to make lipids.
The smooth ER is primarily involved in the synthesis of lipids, including phospholipids and steroids, as well as the metabolism of carbohydrates and the detoxification of drugs and poisons. Therefore, the absence of smooth ER would impair the cell's ability to produce lipids.