What was the most significant impact that the Columbian Exchange had on American Indians?

Question

A.
It led to the introduction of new foods that led to an increase in American Indian populations.
B.
It led to the introduction of new diseases that greatly reduced American Indian populations.
C.
It led to a large movement of American Indian slaves to Europe, Africa, and Asia.
D.
It led to a large movement of American Indian farmers to Europe, Africa, and Asia.

Answer 1

B. It led to the introduction of new diseases that greatly reduced American Indian populations.